User profiles for R. Dantzer

Dantzer r

University of Texas MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 62908

R Dantzer, JC O'Connor, GG Freund… - Nature reviews …, 2008 - nature.com
In response to a peripheral infection, innate immune cells produce pro-inflammatory
cytokines that act on the brain to cause sickness behaviour. When activation of the
peripheral immune system continues unabated, such as during systemic infections, cancer …

R Dantzer, KW Kelley - Brain, behavior, and immunity, 2007 - Elsevier
Cytokine-induced sickness behavior was recognized within a few years of the cloning and
expression of interferon-α, IL-1 and IL-2, which occurred around the time that the first issue
of Brain, Behavior, and Immunity was published in 1987. Phase I clinical trials established …

S Kent, RM Bluthé, KW Kelley, R Dantzer - Trends in pharmacological …, 1992 - Elsevier
Sickness behavior refers to the nonspecific symptoms (anorexia, depressed activity, loss of
interest in usual activities, disappearance of body-care activities) that accompany the
response to infection. Increasing evidence suggests that these symptoms are part of an …

JP Konsman, P Parnet, R Dantzer - Trends in neurosciences, 2002 - Elsevier
Sickness behaviour represents the expression of the adaptive reorganization of the priorities
of the host during an infectious episode. This process is triggered by pro-inflammatory
cytokines produced by peripheral phagocytic cells in with invading micro-organisms …

KW Kelley, RM Bluthé, R Dantzer, JH Zhou… - Brain, behavior, and …, 2003 - Elsevier
The behavioral repertoire of humans and animals changes dramatically following infection.
Sick individuals have little motivation to eat, are listless, complain of fatigue and malaise,
loose interest in social activities and have significant changes in sleep patterns. They …

R Dantzer - Brain, behavior, and immunity, 2001 - Elsevier
Sickness behavior refers to the coordinated set of behavioral changes that develop in sick
individuals during the course of an infection. At the molecular level, these changes are due
to the effects of proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis …

…, J Lestage, N Castanon, KW Kelley, R Dantzer - Molecular …, 2009 - nature.com
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2, 3-
dioxygenase (IDO) has been proposed to mediate comorbid depression in inflammatory
disorders, its causative role has never been tested. We report that peripheral administration …

R Dantzer - Annals of the New York Academy of Sciences, 2001 - Wiley Online Library
Sickness behavior refers to a coordinated set of behavioral changes that develop in sick
individuals during the course of an infection. At the molecular level, these changes are due
to the brain effects of proinflammatory cytokines such as interleukin‐1 (IL‐1) and tumor …

R Dantzer, KW Kelley - Life sciences, 1989 - Elsevier
The old notion that stress exacerbates the progression of physical illness via its
corticosteroid-mediated immunosuppressive effects must be revised. Experimental and
clinical studies demonstrate that both laboratory and natural stressors alter the activities of …

R Dantzer - European journal of pharmacology, 2004 - Elsevier
Sickness refers to a coordinated set of subjective, behavioural and physiological changes
that develop in sick individuals during the course of an infection. These changes are due to
the effects of interleukin-1 (IL-1) and other proinflammatory cytokines on brain cellular …