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Journal Article

General Models for the Joint Action of Mixtures of Drugs

J. R. Ashford
Biometrics
Vol. 37, No. 3 (Sep., 1981), pp. 457-474
DOI: 10.2307/2530559
https://www.jstor.org/stable/2530559
Page Count: 18
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General Models for the Joint Action of Mixtures of Drugs
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Abstract

This paper is concerned with the construction of mathematical models to represent the action of drugs or other stimuli on biological organisms or other complex systems. A framework for a general system of models is set up on the basis of three main concepts: the system and its subsystems, the sites of action, and the components of the stimulus. The classification of joint action in terms of this framework is then considered and a clarification of the standard nomenclature in relation to dependent joint action is put forward. A more specific set of models, based upon a simplified representation of drug-receptor action, is developed within the general framework. Some practical examples of joint action in the context of the models are described.