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The coding‐synonymous polymorphism rs1045280 (Ser280Ser) in β‐arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia

Y.‐J. Liou

Department of Psychiatry, Taipei Veterans General Hospital, Taipei

Institute of Clinical Medicine, School of Medicine, National Yang‐Ming University, Taipei

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Y.‐C. Wang

Yuli Mental Health Research Center, Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien

Institute of Medical Science, Tzu Chi University, Hualien

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J.‐Y. Chen

Yuli Mental Health Research Center, Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien

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M.‐L. Chen

Yuli Mental Health Research Center, Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien

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T.‐T. Chen

Yuli Mental Health Research Center, Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien

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Y.‐M. Bai

Department of Psychiatry, Taipei Veterans General Hospital, Taipei

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C.‐C. Lin

Department of Psychiatry, National Taiwan University Hospital, Taipei

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D.‐L. Liao

Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Miaoli, Taiwan

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I.‐C. Lai

Yuli Mental Health Research Center, Department of Psychiatry, Yuli Veterans Hospital, Yuli, Hualien

Institute of Medical Science, Tzu Chi University, Hualien

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First published: 12 November 2008
Cited by: 14
Dr I.‐C. Lai, Department of Psychiatry, Yuli Veterans Hospital, No. 91, Shin‐Shin St, Yuli, Hualien 981, Taiwan (tel.: +886 3 8883141 ext. 475; fax: +886 3 8887091; e‐mail: [email protected]).

Abstract

Background: Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long‐term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic‐induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as β‐arrestin 2 (ARRB2), an important mediator between DRD2 and serine–threonine protein kinase (AKT) signal cascade.

Methods: A case–control study to evaluate the association between rs1045280 (Ser280Ser) and antipsychotic‐induced TD was performed amongst 381 patients (TD/non‐TD = 228/153).

Results: There was a significant difference in the genotype distribution between TD and non‐TD groups (P =0.025); furthermore, the allelic analysis indicated that patients with T allele had increased risk of TD occurrence (ORT = 1.58, 95% CI = 1.14–2.19, P =0.007).

Conclusions: To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients.

Number of times cited according to CrossRef: 14

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