Journal of Endocrinological Investigation

, Volume 33, Issue 7, pp 472–477 | Cite as

Mineralocorticoid receptor p.I180V polymorphism: Association with body mass index and LDL-cholesterol levels

  • F. L. Fernandes-Rosa
  • A. C. Bueno
  • R. Molina de Souza
  • M. de Castro
  • J. Ernesto dos Santos
  • M. C. Foss
  • M.-C. Zennaro
  • H. Bettiol
  • M. A. Barbieri
  • S. R. AntoniniEmail author
Original Articles


Background/Aims: Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular risk. Design and methods: Case-control study nested within a cohort of 2063 subjects followed since birth to date. All subjects (age 23–25 yr old) from the entire cohort with systolic and diastolic hypertension (no.=126) were paired with 398 normotensive controls. MR p. I180V genotype association with anthropometric and biochemical markers of cardiometabolic risk was tested. Results: There was a significant association of the MR p. I180V genotype with body mass index (BMI) and LDL-cholesterol level (p<0.01). Hypertensive subjects carrying the polymorphic G allele (AG or GG genotypes) presented significantly higher BMI (30.0±6.0 vs 28.7±5.6 kg/m2; p<0.01) and higher LDL-cholesterol (139.9±60.3 vs 109.9±35.5 mg/dl; p<0.01). The frequency of the polymorphism MR p.I180V was similar between hypertensive subjects and controls (p=0.15). Conclusions: The MR p.I180V polymorphism seems to be associated with cardiovascular risk factors including BMI and LDL-cholesterol levels. This original in vivo finding reinforces the role of MR in adipocyte biology and in cardiovascular disease.


Cardiometabolic risk hypertension mineralocorticoid receptor obesity polymorphism 


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Copyright information

© Italian Society of Endocrinology (SIE) 2010

Authors and Affiliations

  • F. L. Fernandes-Rosa
    • 1
  • A. C. Bueno
    • 1
  • R. Molina de Souza
    • 1
  • M. de Castro
    • 2
  • J. Ernesto dos Santos
    • 2
  • M. C. Foss
    • 2
  • M.-C. Zennaro
    • 3
    • 4
    • 5
    • 6
  • H. Bettiol
    • 1
  • M. A. Barbieri
    • 1
  • S. R. Antonini
    • 1
    Email author
  1. 1.Department of Puericulture and PediatricsUniversity of Sao PauloRibeirao PretoBrazil
  2. 2.Department of Internal Medicine, School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil
  3. 3.INSERM U970Paris Cardiovascular Research Center — PARCCParis
  4. 4.Collège de FranceFrance
  5. 5.Faculty of MedicineParis Descartes UniversityFrance
  6. 6.Public Assistance-Paris HospitalsEuropean Hospital Georges PompidouParisFrance

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