Advertisement

Experientia

, Volume 47, Issue 6, pp 616–619 | Cite as

Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase

  • M. Merlos
  • R. M. Sanchez
  • J. Camarasa
  • T. Adzet
Research Articles
  • 42 Downloads

Summary

The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety. Kinetic inactivation studies of the enzyme with the inhibitor quercetin revealed a non-competitive profile versus both glutathione and 1-chloro-2,4-dinitrobenzene.

Key words

Flavonoids glutathione S-transferase quercetin rat liver cytosol 

Preview

Unable to display preview. 

Unable to display preview. 

References

  1. 1.
    Havsteen, B., Biochem. Pharmac.32 (1983) 1141.CrossRef
  2. 2.
    Middleton, E. Jr., Trends pharmac. Sci.5 (1984) 335.
  3. 3.
    Ferrell, J. E., Jr., Chang Sing, P. D. G., Loew, G., King, R., Mansour, J. M., and Mansour, T. E., Molec. Pharmac.16 (1979) 556.
  4. 4.
    Beretz, A., Stierle A., Anton, R., and Cazenave, J. P., Biochem. Pharmac.31 (1982) 3597.CrossRef
  5. 5.
    Middleton, E. Jr., and Drzewiecki, G., Biochem. Pharmac.31 (1982) 1449.CrossRef
  6. 6.
    Varma, S. D., and Kinoshita, J. H., Biochem. Pharmac.25 (1976), 2505.CrossRef
  7. 7.
    Kuriki, Y., and Racker, E., Biochemistry15 (1976) 4951.CrossRef
  8. 8.
    Fewtrell, C. M. S., and Gomperts, B. D., Nature265 (1977) 635.
  9. 9.
    Corvazier, E., and Maclouf, J., Biochim. biophys. Acta835 (1985) 315.
  10. 10.
    Yoshimoto, T., Furukawa, M., Yamamoto, S., Horie, T., and Watanabe-Kohno, S., Biochem. biophys. Res. Commun.116 (1983) 612.
  11. 11.
    Beyeler, S., Testa, B., and Perrisoud, D., Arzneim. Forsch. (Drug Res.)33 (1983) 564.
  12. 12.
    Bears, A. J., and Breirien, D. D., Ann. Biol. clin.38 (1980) 49.
  13. 13.
    Kaplowitz, N., Am. J. Physiol.239 (1980) G439.
  14. 14.
    Das, M., Bickers, D. R., and Mukhtar, H., Biochem. biophys. Res. Commun.120 (1984) 427.CrossRef
  15. 15.
    Habig, W. H., Pabst, M. J., and Jakoby, W. B. J. biol. Chem.249 (1974) 7130.
  16. 16.
    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. S., J. biol. Chem.193 (1951) 265.
  17. 17.
    Beretz, A., Cazenave, J. P., and Anton, R., Agents Actions12 (1982) 382.
  18. 18.
    Gryglewski, R. J., Korbut, R., Robak, J., and Swies, J., Biochem. Pharmac.36 (1987) 317.CrossRef
  19. 19.
    Moroney, M. A., Alcaraz, M. J., Forder, R. A., Carey, F., and Hoult, R. S., J. Pharm. Pharmac.40 (1988) 787.
  20. 20.
    Hodnick, W. F., Kung, F. S., Roettger, W. J., Bohmont, C. W., and Pardini, R. S., Biochem. Pharmac.35 (1986) 2345.CrossRef
  21. 21.
    Wurm, G., Baumann, J., and Geres, U., Dt. Apoth. Z.122 (1982) 2062.
  22. 22.
    Welton, A. F., Tobias, L. D., Friedler-Nagy, C., Anderson, W., Hope, W., Meyers, K., and Coffey, J. W., Prog. clin. biol. Res.213 (1986) 231.
  23. 23.
    Klopman, G., and Dimoyuga, M. L., Molec. Pharmac.34 (1988) 218.
  24. 24.
    Beyeler, S., Testa, B., and Perrissoud, D., Biochem. Pharmac.37 (1988) 1971.CrossRef
  25. 25.
    Kariya, K., Lee, E., and Takamura, Y., Xenobiotica14 (1984) 349.
  26. 26.
    Das, M., Bickers, D. R., and Mukhtar, H., Carcinogenesis6 (1985) 1409.

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • M. Merlos
    • 1
  • R. M. Sanchez
    • 1
  • J. Camarasa
    • 1
  • T. Adzet
    • 1
  1. 1.Laboratory of Pharmacology and Pharmacognosy, School of PharmacyUniversity of BarcelonaBarcelona(Spain)

Personalised recommendations

www.viagraon.com

farm-pump-ua.com