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Article

Mast cells and tumor angiogenesis

David A. Kessler

Department of Surgery, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA

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Robert S. Langer

Department of Surgery, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA

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Naomi A. Pless

Department of Surgery, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA

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Judah Folkman

Department of Surgery, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA

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First published: 15 November 1976
Cited by: 147

Abstract

en

Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.

Abstract

fr

Mastocytes Et Angiogénèse Tumorale

Le facteur d'angiogénèse tumorale (TAF) déclenche une forte réponse vasoproliférative lorsqu'il est implanté sur la membrane chorio‐allantoïdienne de l'embryon de poulet. On observe d'abord cette réponse en stéréomicroscopie deux à trois jours après l'implantation. En 24 h, la densité des mastocytes devient quarante fois forte au voisinage de l'implant. Des mastocytes qui ont été isolés à partir de rats Sprague‐Dawley n'ont pas déclenché de réaction vasculaire lorsqu'on les a implantés sur la membrane chorio‐allantoïdienne. Les auteurs estiment que les mastocytes jouent un rǒle d'intermédiares dans l'angiogénèse tumorale.

Number of times cited according to CrossRef: 147

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