TABLE 10

Information about study length, washout profile, dose schedule, route, and nutritional conditions

Number of saline control animals appears within parentheses.

TreatmentStudyProtocolRouteLean RatsObese Rats
AcuteOn-off 1 h1 h infusioni.v.4 (3)5 (3)
On-off 5 h5 h infusions.c.7 (2)7 (5)
On-off 12 h12 h infusions.c.5 (2)4 (2)
Step-down 1 h1 h infusion 3.5 h of step-down infusioni.v.5 (2)5 (2)
Step-down 12 h12 h infusion 3.5 h of step-down infusions.c.5 (3)4 (3)
Semichronic Continuous 120 h120 h pretreatment infusion 5 h infusions.c.6 (2)8 (2)
Intermittent 120 h120 h pretreatment intermittent infusion (12 h infusion 12 h washout) 5 h infusions.c.6 (2)8 (3)