Abstract
Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP1 and CGRP2. After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP1 receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP2 receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term “CGRP2” receptor should no longer be used, and the “CGRP1” receptor should be known as the “CGRP” receptor.
- The American Society for Pharmacology
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