Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Feedback
  • Other Publications
    • Pharmacological Reviews

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Pharmacological Reviews
  • Other Publications
    • Pharmacological Reviews
  • My alerts
  • Log in
Pharmacological Reviews

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Feedback
Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 2005, 57 (3) 289-298; DOI: stonel.info/10.1124/pr.57.3.1
Steven C. Prinster
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chris Hague
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Randy A. Hall
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological responses to a diverse array of stimuli. GPCRs have traditionally been thought to act as monomers, but recent evidence suggests that GPCRs may form dimers (or higher-order oligomers) as part of their normal trafficking and function. In fact, certain GPCRs seem to have a strict requirement for heterodimerization to attain proper surface expression and functional activity. Even those GPCRs that do not absolutely require heterodimerization may still specifically associate with other GPCR subtypes, sometimes resulting in dramatic effects on receptor pharmacology, signaling, and/or internalization. Understanding the specificity and functional significance of GPCR heterodimerization is of tremendous clinical importance since GPCRs are the molecular targets for numerous therapeutic drugs.

  • The American Society for Pharmacology
View Full Text

Log in using your username and password

Forgot your user name or password?

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

PreviousNext
Back to top

In this issue

Pharmacological Reviews: 57 (3)
Pharmacological Reviews
Vol. 57, Issue 3
1 Sep 2005
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Pharmacological Reviews article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
(Your Name) has forwarded a page to you from Pharmacological Reviews
(Your Name) thought you would be interested in this article in Pharmacological Reviews.
Citation Tools
Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 1, 2005, 57 (3) 289-298; DOI: stonel.info/10.1124/pr.57.3.1

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 1, 2005, 57 (3) 289-298; DOI: stonel.info/10.1124/pr.57.3.1
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • I. Introduction
    • II. Clinical Significance of GPCR Heterodimerization
    • III. Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Stem Cell Approaches for the Treatment of Renal Failure
  • Gastrointestinal Function Regulation by Nitrergic Efferent Nerves
  • Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells
Show more Articles

Similar Articles

pills24.com.ua/levitra-vardenafil/levitra-10-mg/

www.pills24.com.ua/viagra-sildenafil/viagra-25-mg/

pills24.com.ua
  • Home
  • Alerts
      RSS

Navigate

  • Current Issue
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback

More Information

  • Editorial Board
  • Instructions to Authors
  • Customized Alerts
  • RSS Feeds

ASPET's Other Journals

(Online)

Copyright © 2019 Pharmacology